Level of Interaction

Protein Protein Interaction

MicroRNAs are class of small approximately 22nt noncoding(nc) RNAs that regulate gene expression post transcriptionally by direct binding to target sites on mRNAs. They comprise more than 1000 novel species in mammalian cells and exert their function by modulating gene expression through several different mechanism, including translational inhibition, and/or degradation of target mRNAs. Mitochondria are the cell's power producers. They convert energy into forms that are usable by the cell. All functions require several pathways and numerous enzymatic and regulation process. Despite the fact the mitochondrion has its own genomic, transcriptomic and proteomic materials; it is not entirely automomous to produce all the proteins required for its full functionality. Several essential cellular functions of mitochondria depend on a high degree of functional interaction between the nuclear and mitochondrial genomes. More than one thousand proteins have been identified in the mammalian mitochondria. There is need to find all proteins which regulate mitochondrial function and also to find its regulation through microRNA and Transcription factors.

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